NOH is a large academic teaching hospital in the Capital Region of Denmark. The Endocrine Research Unit in the Department of Cardiology, Nephrology and Endocrinology has during the last two decades focused on 1) hypoglycaemia in diabetes, searching for risk factors and exploring their mechanisms, including impaired hypoglycaemia awareness; 2) insulin intervention in hypoglycaemia-prone persons. Research is performed within extensive collaborative networks in the Capital Region of Denmark and beyond. Our hypoglycaemia research group at NOH established in 1998 was first to introduce studies of the genetic influence on the risk for severe hypoglycaemic events (ACE/renin-angiotensin system), and is still one of the leading groups within this issue. We are also highly experienced in investigator-initiated insulin RCTs in hypoglycaemia-prone subjects. The main tasks of NOH will be to lead the formation of a clinical investigator network within the consortium, to participate in human experimental studies of hypoglycaemia, and to participate in a clinical study using continuous glucose monitoring. NOH will furthermore contribute to the analysis of data from the merged clinical trial databases and engage with regulatory authorities to agree on classification and guideline recommendations.
Expert in hypoglycaemia epidemiology, strong track record in translational research on hypoglycaemia in diabetes and insulin therapy. Chair and/or member of several national working groups on type 1 diabetes and continuous glucose monitoring. Member of the International Hypoglycaemia Study Group.
with a long-lasting interest and expertice in insulin kinetics, hypoglycaemia and impaired awareness of hypoglycaemia.
