Publications | Hypo-RESOLVE

2022

Hannah Chatwin, Melanie Broadley, Christel Hendrieckx, Jill Carlton, Simon Heller, Stephanie A. Amiel, Bastiaan de Galan, Rory J. McCrimmon, Ulrik Pedersen-Bjergaard, FransP ouwer, Jane Speight, On behalf of the Hypo-RESOLVE Consortium
The impact of hypoglycaemia on quality of life among adults with type 1 diabetes: Results from “YourSAY: Hypoglycaemia”
Journal of Diabetes and its Complications, Volume 36, Issue 7, 21 June 2022, 108232. https://doi.org/10.1016/j.jdiacomp.2022.108232
Emily O.Staricoff, Mark L.Evans
Recent advances in understanding hypothalamic control of defensive responses to hypoglycaemia
Current Opinion in Endocrine and Metabolic Research, Volume 24, 2022, 100353. https://doi.org/10.1016/j.coemr.2022.100353
Additional link
Patrick Divilly, Natalie Zaremba, Zeinab Mahmoudi, Uffe Søholm, Daniel J. Pollard, Melanie Broadley, Evertine J. Abbink, Bastiaan de Galan, Ulrik Pedersen-Bjergaard, Eric Renard, Mark Evans, Jane Speight, Alan Brennan, Rory J. McCrimmon, Matthias Müllenborn, Simon Heller, Alexander Seibold, Julia K. Mader, Stephanie A. Amiel, Frans Pouwer, Pratik Choudhary, Hypo-RESOLVE Consortium
Hypo-METRICS: Hypoglycaemia—MEasurement, ThResholds and ImpaCtS—A multi-country clinical study to define the optimal threshold and duration of sensor-detected hypoglycaemia that impact the experience of hypoglycaemia, quality of life and health economic outcomes: The study protocol
Diabetic Medicine. 2022;00:e14892. https://doi.org/10.1111/dme.14892
Nunzio Camerlingo, Martina Vettoretti, Simone Del Favero, Andrea Facchinetti, Pratik Choudhary, Giovanni Sparacino, on behalf of the Hypo-RESOLVE Consortium
Generation of post-meal insulin correction boluses in type 1 diabetes simulation models for in-silico clinical trials: More realistic scenarios obtained using a decision tree approach
Comput. Methods Programs Biomed., 221(6): 106862, 2022. https://doi.org/10.1016/j.cmpb.2022.106862
Additional link
Uffe Søholm, Melanie Broadley, Natalie Zaremba, Patrick Divilly, Giesje Nefs, Zeinab Mahmoudi, Bastiaan de Galan, Ulrik Pedersen-Bjergaard, Alan Brennan, Daniel John Pollard, Rory J McCrimmon, Stephanie A. Amiel, Christel Hendrieckx, Jane Speight, Pratik Choudhary, Frans Pouwer
Investigating the day-to-day impact of hypoglycaemia in adults with type 1 or type 2 diabetes: design and validation protocol of the Hypo-METRICS application
BMJ Open 2022;12:e051651. https://doi.org/10.1136/bmjopen-2021-051651
Additional link
Mette Valdersdorf Jensen, Melanie Broadley, Jane Speight, Hannah Chatwin, Alison Scope, Anna Cantrell, Simon Heller, Bastiaan E. de Galan, Christel Hendrieckx, Frans Pouwer, on behalf of the Hypo-RESOLVE consortium
The impact of hypoglycaemia in children and adolescents with type 1 diabetes on parental quality of life and related outcomes: A systematic review
Pediatrics Diabetes, Volume23, Issue3, 2022. https://10.1111/pedi.13308
Additional link
Alexandre Picard, Xavier Berney, Judit Castillo-Armengol, David Tarussio, Maxime Jan, Ana Rodriguez Sanchez-Archidona, Sophie Croizier, Bernard Thorens
Hypothalamic Irak4 is a genetically controlled regulator of hypoglycemia-induced glucagon secretion
Molecular Metabolism, Volume 61, July 2022, 101479. https://doi.org/10.1016/j.molmet.2022.101479
Additional link

2021

Heather J Merchant and Alison D McNeilly
Hypoglycaemia: Still the main drawback of insulin 100 years on : "From man to mouse"
Diabetic Medicine, 2021 Dec;38(12):e14721. https://doi.org/10.1111/dme.14721
Additional link
Nunzio Camerlingo, Martina Vettoretti, Giovanni Sparacino, Andrea Facchinetti, Julia K. Mader, Pratik Choudhary, Simone Del Favero, on behalf of the Hypo-RESOLVE Consortium
Choosing the duration of continuous glucose monitoring for reliable assessment of time in range: A new analytical approach to overcome the limitations of correlation-based methods
Diabet Med. 2021, Dec. 4th; 00:e14758; https://doi:10.1111/dme.14758
Additional Link
Manon Coolen, Melanie Broadley, Christel Hendriecks, Hannah Chatwin, Mark Clowes, Simon Heller, Bastiaan E. de Galan, Jane Speight, Frans Pouwer, for the Hypo-RESOLVE Consortium¶
The impact of hypoglycemia on quality of life and related outcomes in children and adolescents with type 1 diabetes: A systematic review
PLOS ONE, December 2, 2021. https://doi.org/10.1371/journal.pone.0260896
Additional Link
Hannah Chatwin, Melanie Broadley, Christel Hendrieckx, Jill Carlton, Simon Heller, Stephanie A. Amiel, Bastiaan E. de Galan, Norbert Hermanns, Katharina Finke-Groene, Jane Speight, Frans Pouwer, the Hypo-RESOLVE Consortium
Unmet support needs relating to hypoglycaemia among adults with type 1 diabetes: Results of a multi-country web-based qualitative study
Diabetic Medicine. 2021;00:e14727. https://doi.org/10.1111/dme.14727
Additional Link
Zeinab Mahmoudia, Simone Del Favero, PeterJacob, Pratik Choudhary, on behalf of the Hypo-RESOLVE Consortium
Toward an Optimal Definition of Hypoglycemia with Continuous Glucose Monitoring
Computer Methods and Programs in Biomedicine, Volume 209, September 2021, e106303. https://doi.org/10.1016/j.cmpb.2021.106303
Kevin A. Matlock, Melanie Broadley, Christel Hendrieckx, Mark Clowes, Anthea Sutton, Simon R. Heller, Bastiaan E. de Galan, Frans Pouwer, Jane Speight, for the Hypo-RESOLVE consortium,
Changes in quality of life following hypoglycaemia in adults with type 2 diabetes: A systematic review of longitudinal studies
Diabetic Medicine. 2021;00:e14706. https://doi.org/10.1111/dme.14706
Additional link
Hannah Chatwin, Melanie Broadley, Mette Valdersdorf Jensen, Christel Hendrieckx, Jill Carlton, Simon Heller, Stephanie Amiel, Bastiaan de Galan, Norbert Hermanns, Katharina Finke-Groene, Jane Speight, Frans Pouwer
‘Never again will I be carefree’: a qualitative study of the impact of hypoglycemia on quality of life among adults with type 1 diabetes
BMJ Open Diab Res Care 2021 Aug; 9:e002322. https://doi.org/10.1136/bmjdrc-2021-002322
Additional link
Mette Valdersdorf Jensen, Melanie Broadley, Jane Speight, Alison Scope, Louise Preston, Simon Heller, Bastiaan E. de Galan, Frans Pouwer, Christel Hendrieckx, the Hypo-RESOLVE Consortium
The impact of hypoglycaemia on the quality of life of family members of adults with type 1 or type 2 diabetes: A qualitative systematic review
Diabet Med, e14666, July 2021. https.//doi.org/doi:10.1111/dme.14666.
Additional link
Nunzio Camerlingo, Martina Vettoretti, Giovanni Sparacino, Andrea Facchinetti, Julia K. Mader, Pratik Choudhary, Simone Del Favero, on behalf of the Hypo-RESOLVE Consortium
Design of clinical trials to assess diabetes treatment: minimum duration of continuous glucose monitoring data to estimate time-in-ranges with the desired precision
Diabetes Obes. Metab., 2021, July, 1st. https://doi.org/10.1111/dom.14483
Additional Link
C. Roversi, M. Vettoretti, S. Del Favero, A. Facchinetti, P. Choudhary, G. Sparacino
Impact of Carbohydrate Counting Error on Glycemic Control in Open-Loop Management of Type 1 Diabetes: Quantitative Assessment Through an in silico Trial
J Diabetes Sci Technol, 2021 May 12; https://doi.org/10.1177/19322968211012392
Additional Link
Alexandre Picard, Salima Metref, David Tarussio, Wanda Dolci, Xavier Berney, Sophie Croizier, Gwenaël Labouebe and Bernard Thorens.
Fgf15 Neurons of the Dorsomedial Hypothalamus Control Glucagon Secretion and Hepatic Gluconeogenesis
Diabetes 2021;70(7):1443–1457. https://doi.org/10.2337/db20-1121
Additional Link
Hannah Chatwin, Melanie Broadley, Jane Speight, Anna Cantrell, Anthea Sutton, Simon Heller, Bastiaan de Galan, Christel Hendrieckx, Frans Pouwer; For the Hypo-RESOLVE Consortium
The Impact of Hypoglycaemia on Quality of Life Outcomes Among Adults with Type 1 Diabetes: A Systematic Review
Diabetes Research and Clinical Practice, Volume 174, 108752, April 01, 2021. https://doi.org/10.1016/j.diabres.2021.108752
Additional Link
Keeran Vickneson; Jessica Blackburn; Jennifer R. Gallagher; Mark L. Evans, Bastiaan E. de Galan, Ulrik Pedersen-Bjergaard, Bernard Thorens, Alison D. McNeilly, Rory J. McCrimmon
Cold-induced dishabituation in rodents exposed to recurrent hypoglycaemia.
Diabetologia volume 64, pages 1436–1441 (2021). https://doi.org/10.1007/s00125-021-05425-3
Addtional Link
Carlton J, Leaviss J, Pouwer F, Hendreickx C, Broadley MM, Clowes M, McCrimmon RJ, Heller SR, Speight J
The suitability of patient-reported outcome measures used to assess the impact of hypoglycaemia on quality of life in people with diabetes: a systematic review using COSMIN methods.
Diabetologia 64, 1213–1225 (2021). https://doi.org/10.1007/s00125-021-05382-x.
Additional Link
Omar Diouri, Monika Cigler, Martina Vettoretti, Julia K. Mader, Pratik Choudhary, Eric Renard, HYPO‐RESOLVE Consortium
Hypoglycaemia detection and prediction techniques: A systematic review on the latest developments
DiabetesMetab Res Rev. 2021;e344. https://doi.org/10.1002/dmrr.3449
Additional Link
Therese W. Fabricius, Clementine E.M. Verhulst, Peter L. Kristensen, Cees J. Tack, Rory J. McCrimmon, Simon Heller, Mark L. Evans, Stephanie A. Amiel, Thomas R. Pieber, Bastiaan E. de Galan, Ulrik Pedersen-Bjergaard, on behalf of the Hypo-RESOLVE consortium
Hyperinsulinaemic-hypoglycaemic glucose clamps in human research – a systematic review of the literature and a proposal of a standardized protocol
Diabetologia (2021). https://doi.org/10.1007/s00125-020-05361-8
Additional Link

2020

Simon Quenneville; Gwenaël Labouèbe; Davide Basco; Salima Metref; Benoit Viollet; Marc Foretz; Bernard Thorens
Hypoglycemia-Sensing Neurons of the Ventromedial Hypothalamus Require AMPK-Induced Txn2 Expression but Are Dispensable for Physiological Counterregulation
Diabetes 2020;69(11):2253–2266
Additional Link
Camerlingo N, Vettoretti M, Del Favero S, Facchinetti A, Sparacino G.
Mathematical Models of Meal Amount and Timing Variability With Implementation in the Type-1 Diabetes Patient Decision Simulator
J Diabetes Sci Technol., 2020 Sep 17:1932296820952123, doi: 10.1177/1932296820952123
Additional Link
Suresh Rama Chandran, Peter Jacob, Pratik Choudhary
Baseline Glucose Variability and Interweek Variability Affects the Time to Stability of Continuous Glucose Monitoring-Derived Glycemic Indices
Diabetes Technology & Therapeutics, doi: 10.1089/dia.2020.0011
Additional Link
Camerlingo N, Vettoretti M, Facchinetti A, Sparacino G, Mader JK, Choudhary P, Del Favero S.
An analytical approach to determine the optimal duration of continuous glucose monitoring data required to reliably estimate time in hypoglycemia.
Sci Rep. 2020 Oct 23;10(1):18180. doi: 10.1038/s41598-020-75079-5.
Additional Link
Chiara Roversi, Martina Vettoretti, Simone Del Favero, Andrea Facchinetti, Giovanni Sparacino
Modeling carbohydrate counting error in type 1 diabetes management
Diabetes Technology & Therapeutics, doi: 10.1089/dia.2019.0502
Additional Link
de Galan BE, McCrimmon R, Ibberson M, Heller SR, Choudhary P, Pouwer F, Speight J, Carlton J, Pieber TR, Rosilio M, Tack CJ, Müllenborn M; Hypo-RESOLVE Consortium
Reducing the Burden of Hypoglycaemia in People with Diabetes through Increased Understanding: design of the Hypoglycaemia REdefining SOLutions for better liVEs (Hypo-RESOLVE) study
Diabetic Medicine, Vol. 37, Issue6 June 2020, pp. 1066-1073.doi: 10.1111/dme.14240
Additional Link