United Kingdom

The University of Sheffield is a world top-100 according to the results of the 2014 Research Excellence Framework (REF). Two units at the University of Sheffield will be contributing to this project: the Department of Human Metabolism and the School of Health and Related Research (ScHARR). The Department of Oncology and Metabolism has a major interest in hypoglycaemia and diabetes including educational interventions to reduce hypoglycaemia (DAFNE and HYPO-Doc, cardiovascular consequences of hypoglycaemia, including arrhythmias), mechanisms of hypoglycaemia unawareness. ScHARR has a long standing interest in multiple themes in Health Economic research. These include developing and valuing patient report outcome measures, conducting economic evaluations both with mathematical models and using data collected in clinical studies. The Department of Human Metabolism will be leading work on classification of hypoglycaemia, developing the main clinical questions to be answered by analyses of the database (WP4), developing, interpreting, summarizing and disseminating statistical analyses using clinical and research skills in hypoglycaemia. We will also be working closely with work packages, in particular WP5 and contributing to the design of the clinical trial. ScHARR will be working closely with other work packages. We will be looking at how well current patient reported outcomes (PROs) can measure the impact of hypoglycaemia on people with diabetes. We will be developing (or refining) a PRO that can be used in a number of settings, such as routine clinical care, trials and in economic evaluations. We will also be looking at the financial costs of hypoglycaemia to the health care system in five European countries.

Prof. Simon Heller

Prof. of Clinical Diabetes. A clinical investigator studying varied topics of immediate clinical relevance in the pathophysiology hypoglycaemia, clinical studies of educational interventions, new insulins to reduce hypoglycaemia in people with diabetes. His research group has an international profile in exploring the relationship between hypoglycaemia and adverse cardiovascular outcomes including cardiac arrhythmias. He is currently National Diabetes Specialty Lead for the NIHR Clinical Research Network and an NIHR senior investigator. He has chaired the International Hypoglycaemia Study Group since its formation, 5 years ago.

Dr Andrew Booth

Reader in Evidence Based Information Practice and Director of Information. Lead on systematic review in WP4. A systematic review methodologist. Research interest focus on all methods of systematic review, evidence synthesis, evidence based practice, and knowledge translation.

Prof. Alan Brennan

Prof. of Health Economics and Decision Modelling. Researches mathematical modelling approaches to inform decision making in health and healthcare. International profile in conducting economic evaluations in Type 1 and 2 diabetes.

Dr Jill Carlton

Senior Research Fellow in Health Economics. Will lead on development and valuation of the new PRO for WP7. Research interests are health-related quality of life and patient outcome measures. Researcher Development Award to undertake PhD designing a paediatric disease-specific health related quality of life measure for amblyopia. Currently working on projects that use patient reported outcome measures and health-related quality of life including the development of a recovery instrument for use in mental health (ReQoL: Recovery of Quality of Life); and EUSCREEN Project to develop equitable cost-effective vision screening throughout Europe, and evaluating the importance of self-management in diabetes (ESMiD).

Mr Daniel Pollard

Research associate in Health Economics and Decision Modelling. Will lead on resource use and costing new PRO for WP7. MSc in Health Economics from York and has been involved in modelling projects in many different disease areas, including type 1 diabetes, cancer screening, acute coronary syndrome and the diagnosis of suspected pulmonary embolism in pregnant women. Current projects include: A systematic review of psychological interventions to improve the motivation for self-management in people with type 1 and type 2 diabetes, and undertaking the health economic modelling for DAFNEplus: Developing and trialling the DAFNEplus (Dose for Adjustment for Normal Eating) intervention. A lifelong approach to promote effective self-management in adults with type 1 diabetes.

Prof. John Brazier

Professor of Health economics and Dean of the School of Health and Related Research (ScHARR) at the University of Sheffield. John is also Director of the Economic Evaluation Policy Research Unit (EEPRU) joint York funded by the Department of Health in England to undertake applied and methodological research to inform health policy in England. John has more than 25 years’ experience of conducting economic evaluations of health care interventions for policy makers and have published over 200 peered reviewed papers. Special interest is in the measurement and valuation of health for economic evaluation, perhaps best known for my work in developing a preference-based measure of health for the SF-36 (SF-6D), but with colleagues have further developed and extended these methods to a number of specific condition including measures in asthma, cancer, overactive bladder, diabetes, mental health, dementia and epilepsy.

Dr Richard Jacques

Lecturer in medical Statistics. PhD investigating methods of classification for high content screening data. Research Interests in application of statistics in medical research, analysis of routinely collected data, multivariate data analysis. Current Projects include Pre-hospital Outcomes for Evidence Based Evaluation (PhOEBE), Understanding variation in rates of ambulance service 'non-conveyance of patients to an emergency department' (VAN), Avoiding Attendance and Admission in Long Term Conditions & Identifying Drivers of Demand for Emergency and Urgent Care. Richard has worked on Type 1 diabetes trails including the REPOSE insulin pump trial.