The University of Sheffield is a world top-100 according to the results of the 2014 Research Excellence Framework (REF). Two units at the University of Sheffield will be contributing to this project: the Department of Human Metabolism and the School of Health and Related Research (ScHARR). The Department of Oncology and Metabolism has a major interest in hypoglycaemia and diabetes including educational interventions to reduce hypoglycaemia (DAFNE and HYPO-Doc, cardiovascular consequences of hypoglycaemia, including arrhythmias), mechanisms of hypoglycaemia unawareness. ScHARR has a long standing interest in multiple themes in Health Economic research. These include developing and valuing patient report outcome measures, conducting economic evaluations both with mathematical models and using data collected in clinical studies. The Department of Human Metabolism will be leading work on classification of hypoglycaemia, developing the main clinical questions to be answered by analyses of the database (WP4), developing, interpreting, summarizing and disseminating statistical analyses using clinical and research skills in hypoglycaemia. We will also be working closely with work packages, in particular WP5 and contributing to the design of the clinical trial. ScHARR will be working closely with other work packages. We will be looking at how well current patient reported outcomes (PROs) can measure the impact of hypoglycaemia on people with diabetes. We will be developing (or refining) a PRO that can be used in a number of settings, such as routine clinical care, trials and in economic evaluations. We will also be looking at the financial costs of hypoglycaemia to the health care system in five European countries.