The Medical University of Graz is the second largest Medical University of Austria with more than 2.200 employees conducting research, education and patient care for the benefit of health. The adjacent university hospital is a hub of innovative and high-end medicine and provides tertiary care services for the south-east of Austria. The Division of Endocrinology and Diabetology at the Department of Internal Medicine offers extensive outpatient services and a 21-bed inpatient ward for patients with diabetes, obesity and endocrine disease. Research interests of the Division focus on areas such as diabetes technology, hypoglycaemia and new pharmaceutical approaches for the treatment of diabetes mellitus. As tertiary center for patients with diabetes and endocrine diseases attending physicians play an important role in communication and negotiations with local, national and European agencies with regard to approval and preconditions for funding of novel drugs and medical devices.
The research group has a strong track record in diabetes technology with abundant expertise in the application and interpretation of continuous glucose monitoring signals, and is considered one of the leading centres in artificial pancreas research and decision support systems for the treatment of diabetes, both aiming to minimize the risk of hypoglycaemia. MUG will be the Work Package lead of WP8 with the main tasks to present novel definitions of hypoglycaemia and to facilitate the acceptance of continuous and flash glucose monitoring as novel methods to assess glycaemia during clinical studies for regulatory approval to notified bodies. Not only biochemical hypoglycaemia but also measures of psychosocial effects and economic burden of hypoglycaemia will be addressed. Within WP 5 MUG will conduct clinical trials as well as analyse existing clinical trial datasets in order to investigate the impact of continuous glucose monitoring-detected low values on biological, patient reported and health-economic outcomes and to provide guidance for its successful use in clinical trials.