Originally scheduled to take place in Wiesbaden, Germany, from 13-14 May 2020, the Hypo-RESOLVE Annual Progress Meeting 2020 had to be reorganised as a web meeting in face of the COVID-19 pandemic. Owing to the virtual format the concise agenda concentrated strongly on presenting the status of the project, discussing challenges and planning future activities as well as assessing the impact of the COVID-19 confinement measures on Hypo-RESOLVE. After a warm welcome by the Coordinator Prof Bastiaan de Galan from Radboud University Medical Center and the Project Leader Dr Stephen Gough from Novo Nordisk, the IMI JU Project Officer for Hypo-RESOLVE, Dr Magda Gunn, who kindly accepted the consortium’s invitation to join the meeting, addressed the plenum. Her presentation was followed by a dedicated Patient Advisory Committee (PAC) session to introduce new members on the committee, present its future agenda and also stress the importance of patients’ involvement in this project. The remainder of the morning session was dedicated to data and analysis and respective advancements achieved, while the first afternoon session focused on consequences of hypoglycaemia, particularly highlighting the extraordinary progress the researchers made in this field during the past year. An interactive session centring on Patient Reported Outcomes (PROs) rounded off the first day. On the second day, the Work Package Leaders presented a status update of the individual work packages and outlined the impact of the COVID-19 measures on their particular work. Despite the remarkable progress made in all areas of the project, it became apparent that the special situation and ongoing restrictions are starting to cause considerable challenges that will have to be taken into account in the following months. The second day closed with the General Assembly meeting, which was led by Project Leader Novo Nordisk supported by Project Management Partner Eurice and focused on consortium management updates. The progress in Hypo-RESOLVE over the past two years was more than reassuring, thanks to the partners’ continuous efforts and valuable contributions towards the project’s goals. The consortium agreed that next year’s annual meeting should take place in Wiesbaden, as was originally foreseen for this year’s meeting, provided that the COVID-19 situation will have cleared by then.